And here's the input for the above (tested and working in September 2019):
\documentclass{book}
% Set up things for XeLaTeX, and Devanagari.
% Simplified version of http://cikitsa.blogspot.com/2010/07/xelatex-for-sanskrit.html
\usepackage{polyglossia} % the multilingual support package
% Next, from the polyglossia manual:
\setdefaultlanguage{sanskrit} % this is mostly going to be Sanskrit,
\setotherlanguage{french} % with some French embedded in it,
\setotherlanguage{english} % and some English.
% These will call appropriate hyphenation.
\usepackage{xltxtra} % standard for nearly all XeLaTeX documents
\defaultfontfeatures{Mapping=tex-text} % ditto
\setmainfont{Gandhari Unicode} % could be any Unicode font
% Now define the Devanagari font:
% John Smith's Sahadeva, input using standard UTF8 transliteration
\newfontfamily\sanskritfont [Script=Devanagari,Mapping=RomDev]{Sahadeva}
% Now come the commands for the critical edition formatting:
\usepackage[noeledmac]{ledmac} %"noeledmac" stops some annoying messages
% customizations to Ledmac, and macros to make life easier.
\def\Variant#1{\Afootnote{\relax#1}}
\def\Lemma#1{\lemma{\relax#1}}
\let\Reference=\Bfootnote
\let\Grammatical=\Cfootnote
\let\Tibetan=\Dfootnote
% in a real edition, I'd probably also make
% abbreviations for \textfrench (perhaps \tf) etc.
\def\Omission#1{$\langle$#1$\rangle$}
\def\ScribalDeletion#1{{\rm[\kern-.15em[}#1{\rm]\kern-.15em]}}
\def\hardspace{\texttt{\char`\ }}
\def\And{{\rm\penalty-1\quad$\mid\mid$~}} % divider between variants to the same lemma
% more customizations: make the A notes
% (\Variants and \Lemmas)into two-column format,
% and make the B notes (\Reference) normal footnotes.
%
% changes to stuff cut-and-pasted from ledmac.sty:
\makeatletter
\renewcommand*{\twocolfootfmt}[3]{%
\normal@pars
% \hsize .45\hsize
\hsize .49\hsize
\parindent=0pt
\tolerance=5000
\raggedright
\leavevmode\hangindent1.5em\hangafter1
\strut{\notenumfont\printlines#1|}\enspace
{\select@lemmafont#1|#2}\rbracket\enskip
#3\strut\par\allowbreak}
\foottwocol{A}
\renewcommand*{\normalfootfmt}[3]{%
\normal@pars
\parindent=0pt \parfillskip=0pt plus 1fil
\hangindent1.5em\hangafter1
{\notenumfont\printlines#1|}\strut\enspace
{\select@lemmafont#1|#2}\rbracket\enskip#3\strut\par}
\footnormal{B}
\makeatother
\firstlinenum{1}
\linenumincrement{1}
% and here begins the edition:
%
\begin{document}
\chapter*{yogaśatakam}
\large
\textenglish{From \emph{Yogaśataka: Texte m\'edical attribu\'e
\`a Nāgārjuna\ldots par Jean Filliozat} (Pondich\'ery, 1979), pp.\,1, 59:\par}
\bigskip
kṛtsnasya tantrasya gṛhītadhāmna-\\
ścikitsitādviprasṛtasya dūram|
vidagthavaidyapratipūjitasya\\
kariṣyate yogaśatasya bandhaḥ|| 1||
\bigskip
\section*{\textenglish{The example verse, with apparatus}}
% we could use the \stanza command, but I haven't bothered.
%
% I find that the judicious use of indentation
% and newlines helps enormously to see what's what.
% Using a good "folding editor" would be even better.
%
\begingroup
\beginnumbering
\autopar
\edtext{
\edtext{kṛtsnasya}{
\Variant{%
\textfrench{N1 détruit, C1 }kṛtas tasya,
\textfrench{C2 }kṛtasya.}
\Tibetan{\textfrench{T \emph{mth'yas}, ``sans limite, immense''
traduit }kṛtsnasya.}}
traduit }kṛtsnasya.}}
tantrasya
\edtext{gṛhītadhāmna-}{
\Variant{\textfrench{Ca, JK }dhamnā.}}\\
\edtext{ścikitsitā}{
\Lemma{cikitsitād} % not ``ścikitsitā'', of course. We're preserving
the sandhyakṣaras.
the sandhyakṣaras.
\Variant{\textfrench{C1, C2 } cikitsitāt.}
\Tibetan{\textfrench{T \emph{gso-spyad} ''pratique de la
thérapeutique''. Ordinairement
thérapeutique''. Ordinairement
\emph{gso spyad} est ``investigation del la th.''}}}% comment sign to stop a break after the conjunct
\edtext{dviprasṛtasya}{
\Lemma{viprasṛtasya} % as above with cikitsitād.
\Variant{\textfrench{Ca} cikitsitārthaprasṛtasya, \textfrench{C1, C2}
viprasutasya.}}
viprasutasya.}}
\edtext{dūram}{
\Variant{\textfrench{Ca} dūrāt}}|
\\ \indent
%
% the above line is annoying. Because the whole verse is
% inside an \edtext{} macro, in order to get the
% \Grammatical note naming the upajāti verse, we have to
% avoid having paragraph breaks, which are not allowed
% inside \edtext{}.
% instead, we use \\ (newline) and \indent (paragraph indent)
% to get the same visual effect. A nasty kludge.
%
vidagdhavaidyapratipūjitasya\\
\edtext{kariṣyate}{
\Variant{\textfrench{N1} karikṣete.}}
yogaśatasya bandhaḥ|| 1||
}{\Lemma{}\Grammatical{Upajāti.}}
\par % necessary to stop \autopar complaining. Thanks to Alessandro Graheli.
\endgroup
\end{document}
